Evolución de menores diagnosticados con trastorno de déficit de atención e hiperactividad. Estudio de seguimiento en una muestra española / Evolution of children diagnosed with attention deficit/hyperactivity disorder. Follow-up study in a Spanish sample

Resumen Antecedentes: El trastorno de déficit de atención e hiperactividad (TDAH) constituye una condición crónica con riesgos asociados a largo plazo. Objetivo: Analizar el estado clínico, la ocupación y las dificultades de la vida diaria de dos cohortes de niños con diagnóstico de TDAH (2004 y 2009) después cinco y 10 años. Material y método: Estudio descriptivo y longitudinal de la base de datos WOMI correspondiente a Oviedo, Asturias, España. Se incluyeron niños detectados con TDAH por su pediatra de atención primaria. Se solicitó una entrevista telefónica voluntaria de seguimiento. Las variables de resultado fueron estado clínico y ocupacional al momento de la entrevista, síntomas de TDAH según SNAP-IV y Cuestionario de Fortalezas y Dificultades (SDQ). Resultados: La muestra entrevistada estuvo formada por 95 sujetos, de los cuales 71 respondieron a los cuestionarios SNAP-IV y SDQ; 60.7 % de la muestra no recibía tratamiento en el momento del seguimiento, 4.7 % no tenía ninguna ocupación, 25.4 % mantenía síntomas globales de TDAH en nivel superior al punto de corte clínico y 66.2 % presentaba dificultades con interferencia moderada. Conclusiones: Los síntomas del TDAH disminuyen conforme las personas crecen. Las comorbilidades de salud mental y el abandono académico no se confirmaron en la muestra.

Abstract Background: Attention deficit/hyperactivity disorder (ADHD) is a chronic condition with long-term associated risks. Objective: To analyze the clinical status, occupation, and daily life difficulties of two cohorts of children diagnosed with ADHD (2004 and 2009) after five and 10 years. Material and method: Descriptive, longitudinal study using the WOMI database corresponding to Oviedo, Asturias, Spain. Children with ADHD detected by their primary care pediatrician were included. A voluntary follow-up telephone interview was requested. Outcome variables were current clinical and occupational status, ADHD symptoms according to SNAP-IV, and Strengths and Difficulties Questionnaire (SDQ). Results: The interviewed sample consisted of 95 subjects, out of whom 71 answered the SNAP-IV and SDQ questionnaires; 60.70% of the sample did not receive treatment at the time of follow-up, 4.7% had no occupation, 25.40% still had ADHD global symptoms above the clinical cutoff point, and 66.2% had difficulties with moderate interference. Conclusions: ADHD symptoms decline as people grow up. Mental health comorbidities and academic dropout were not confirmed in the sample.

Association Of Socio-Demographic Determinants with Economic Burden Among Road Traffic Accident Victims: A Longitudinal Study

Background: RTA are the sixth leading cause of death in India with a greater share of hospitalization, disabili-ties, deaths and socio-economic losses. The study was conducted to assess the socio-demographic determi-nants associated with households’ economic burden among RTA victims. Methods: A longitudinal study was conducted for 2 years in Puducherry employing simple random sampling to include 169 accident victims. Baseline data was collected with a semi-structured questionnaire on socio-demographic details, direct and indirect costs towards road traffic injuries. Follow up was at 6th and 12thmonth from the day of accident. Data entry and analysis were performed using Epi-data. Written informed consent from each participant was sought. Ethical clearance received. Results: Mean age of the accident victims was 36.2 (11.4) years. The median (IQR) for direct, indirect and to-tal expenses were INR 1500 (1000-22100), 18000 (2400-46500) and 3000 (1037-47125) respectively. Asso-ciation between the median (IQR) indirect expenses and marital status as well as socio-economic status of vic-tims were found to be statistically significant. Conclusion: Accident victims and their family faced financial burden, as a large proportion of victims were from productive age group belonging to lower- and middle-class income group

Anxiety, sleep habits and executive function during the COVID-19 pandemic through parents' perception: a longitudinal study

Abstract The present study therefore aims to examine trait and state anxiety, sleep habits and executive functioning during 1 year and a half of the COVID-19 pandemic in children and adolescents through the lens of parents. Assessments were conducted at three different times: April 2020 (T1), October 2020 (T2) and October 2021 (T3). The main sample included 953 children and adolescents aged 6 to 18 years, and scales were used to assess anxiety (STAIC), sleep habits (BEARS) and executive functioning (BRIEF-2). The results showed that 6 months after the outbreak of the pandemic, state and trait anxiety, sleep disturbances and executive dysfunctions increased significantly. One and a half year later, trait anxiety and sleep disturbances have been maintained, while state anxiety and executive dysfunction have decreased their scores obtaining scores similar to those of April 2020. In conclusion, there has been a further decrease in children and adolescents' mental health since the beginning of the pandemic, and it seems to remain at the present time, such as trait anxiety as a part of the personality.

Longitudinal study of psychological distress trajectory and influencing factors in patients with primary acute myocardial infarction / 中国实用护理杂志

Objective:To explore the changes and influencing factors of psychological distress in patients with primary acute myocardial infarction (AMI) in different periods, and to provide reference for the management of psychological distress in patients with primary AMI.Methods:This was a longitudinal, prospective, observational study. From June 2021 to September 2022, 118 patients with primary AMI in Peking Union Medical College Hospital and Peking University First Hospital were selected as the research objects. The psychological distress level of patients was investigated on the points of 24 hours after illness (T 1), before discharge (T 2), 1 month after discharge (T 3), 3 months after discharge (T 4), 6 months after discharge (T 5) and 12 months after discharge (T 6), and the influencing factors were analyzed. Results:The detection rate of psychological distress in 6 follow-up survey nodes was 66.95% (79/118), 48.31% (57/118), 29.66% (35/118), 24.58% (29/118), 19.49% (23/118) and 15.25% (18/118) respectively. Education level, family per capita income and disease awareness had significant effects on the psychological distress of patients with primary AMI at the time points from T 1 to T 6 ( β values were - 1.262 to - 0.212, all P<0.05). Conclusions:The level of psychological distress in primary AMI patients decreased with time. Nursing staff should pay attention to the trajectory and influencing factors of psychological pain, and formulate targeted intervention measures to reduce the level of psychological pain and promote the comprehensive rehabilitation of patients.

Longitudinal study on the track of postoperative supportive care needs and influencing factors in patients with non-small cell lung cancer / 中国实用护理杂志

Objective:To explore the potential categories of post-operative supportive care demand trajectory for patients with non-small cell lung cancer (NSCLC), analyze the influencing factors, and propose targeted interventions.Methods:This was a prospective observational study. A convenient sampling method was used to select 177 NSCLC patients who received surgical treatment in Shanghai Lung Hospital Affiliated to Tongji University from January 2021 to February 2022. The Supportive Care Demand Scale for cancer patients was used to investigate the level of patients′supportive care demand 1 day before operation, 3 days after operation, 1 day before discharge, 1 week after discharge, 1 month after discharge, and 3 months after discharge, and the potential growth model was used to identify the trajectory category and multi category Logistic regression analysis was used to explore the influencing factors.Results:Three supportive care demand trajectories were fitted out in this study, which were the continuous high demand group (46.33%), the slowly decreasing demand group (30.51%), and the low decreasing demand group (23.16%). With the potential category group 3, low demand reduction group as the reference category, Logistic regression analysis showed that high psychological distress, low social support, high disease stage, high comorbidities were more likely to enter the continuous high demand group ( OR = 0.826 to 18.526, all P<0.05), and high education level (college education and above and high school) were more likely to enter the slowly decreasing demand group ( OR = 6.076, 4.199, both P<0.05). Conclusions:The demand track of NSCLC patients for supportive care after surgery has population heterogeneity. Clinical medical staff should provide personalized social support and emotional support for patients with high disease stage, more complications and low education level in the early postoperative period.

Influence of Gestational Age on Eruption of Primary Teeth in Indian Children - A Prospective Longitudinal Study

Context: Eruption of primary teeth is the most anticipated event in a child’s life. Genetics, gender, socio?economic status, gestational age are a few of the determinants of the primary teeth eruption. However, the effect of gestational age on the timing of primary teeth eruption among the Indian population has not been explored to date. Aim: The study was conducted to evaluate the influence of gestational age on time and sequence of eruption of primary teeth among children of Mysore. Settings and Design: A prospective longitudinal cohort study design was conducted at ‘Baby Oral Health Promotion Clinic’ at the Department of Paediatrics, JSS Hospital, Mysore. Methods and Material: 150 newborn babies were recruited by simple random sampling and followed up from birth to 36 months. Teeth present during each visit were recorded. Data were statistically analysed and interpreted. Statistical Analysis Used: Descriptive statistics, t?test for an independent sample, and Pearson’s Chi?squared test were applied. Results: The mandibular central incisor was the first tooth to erupt. Statistically insignificant early eruption in males was noted in both term and preterm children. When the chronological ages were compared, the preterm group showed a statistically significant delay in the eruption of all the teeth. However, when the age was adjusted for prematurity, only the central incisors and second molars showed a statistically significant delay. Conclusions: Gestational age has a strong significant association with the eruption of primary teeth and maybe one of the strong predictors for delayed eruption among children of Mysore.

Trayectorias de fragilidad y factores relacionados en la población de adultos mayores en México / Trajectories of frailty and related factors of elderly people in Mexico

Resumen Introducción: la fragilidad es un indicador del estado de salud en la vejez y un síndrome clínico común en adultos mayores; conlleva un elevado riesgo de resultados deficientes de salud que incluyen caídas, incidentes de discapacidad, hospitalización y mortalidad. Este estudio tuvo como objetivo identificar las diferentes trayectorias de la fragilidad y los factores relacionados con esta entre adultos mayores mexicanos a lo largo del tiempo. Metodología: los datos provienen de un panel de cuatro rondas compuesto por adultos mayores mexicanos y desarrollado de 2001 a 2015 por el Estudio Nacional de Salud y Envejecimiento en México (ENASEM). La fragilidad es la acumulación de déficits a partir de un índice de fragilidad. Se aplicó un análisis multinivel, utilizando modelos jerárquicos para conocer los cambios de trayectorias de fragilidad y qué factores se relacionan con ella. Resultados: ser mujer mayor, viuda y tener un bajo nivel educativo fueron factores de riesgo para un índice de fragilidad alto y una menor satisfacción financiera o realizar actividades en el hogar tienen efectos adversos. Conclusiones: se halló una prevalencia de la fragilidad según la proporción de déficits que poseen los individuos y sus primordiales componentes asociados. Se requiere mejorar las condiciones socioeconómicas de salud en fases previas a la vejez con miras a evitar la presencia de fragilidad en el futuro.

Abstract Introduction: Frailty is an indicator of health status in old age and a common clinical syndrome in older adults that carries an increased risk of poor health outcomes, including falls, incidents of disability, hospitalization, and mortality. This study aimed to identify the different trajectories of frailty and the factors related to frailty among Mexican older adults over time. Methods: Data are from a four-wave panel composed of older Mexican adults from 2001 to 2015 of the Mexican Health and Aging Study (MHAS). Frailty is the accumulation of deficits using a frailty index. A multilevel analysis, using hierarchical models, was applied to know the changes of frailty trajectories and what factors are related to it. Results: Being female, older, being widowhood, and having a lower level of education were risk factors for having a high frailty index and lower financial satisfaction doing activities at home have adverse effects. Conclusion: The findings of this work present information about the prevalence of frailty considering the proportion of deficits that individuals possess and their main associated components in older Mexican adults. It is necessary to improve socioeconomic health conditions in phases before old age to avoid developing frailty in the future.

Estudio longitudinal de la ansiedad escolar en niños chilenos de educación primaria / Longitudinal Study Of School Anxiety In Chilean Children In Primary Education

Resumen Desde la teoría tridimensional, la ansiedad escolar se define como un conjunto de síntomas que se emiten desde tres sistemas de respuesta. El objetivo de este estudio fue evaluar las respuestas de ansiedad escolar en estudiantes chilenos de educación primaria para determinar los posibles cambios a nivel temporal. Para ello, se contó con 155 niños de tres cursos distintos, a quienes se les evaluó el nivel de ansiedad escolar durante tres años consecutivos. El instrumento utilizado fue el Inventario de Ansiedad escolar para la educación primaria (IAEB), que mide la respuesta de ansiedad de tipo cognitiva, psicofisiológica y motora. Se realizaron análisis de varianza de medidas repetidas para determinar la estabilidad temporal. Los resultados indican que la media no mostró diferencias estadísticamente significativas y se mantuvo la ansiedad escolar en estos niños en el periodo de tres años. Se apoyó la posibilidad de que se presente como un síntoma estable de los estudiantes, más que responder a eventos puntuales del entorno.

Abstract Since the three-dimensional theory, school anxiety is defined as a set of symptoms arising from three response systems. The objective of this study was to evaluate school anxiety responses in Chilean primary school students, during three consecutive years, to determine possible changes over time. To this end, 155 children from three different courses were included; they were evaluated for their level of school anxiety for three consecutive years. The instrument used for this was the School Anxiety Inventory for Primary Education (IAEB), which measures the cognitive, psychophysiological and motor anxiety responses. Analysis of variance of repeated measures was performed to determine temporal stability. The results indicated that the mean did not show statistically significant differences, maintaining school anxiety in these children over the three-year period, supporting the possibility that it appears as a stable symptom of the students, rather than responding to specific events in the environment.

Estabilidad diagnóstica de niños con trastorno del espectro autista en la adolescencia (TEA). Funcionamiento ejecutivo, socio-adaptativo y conductual / Diagnostic stability of children with autism spectrum disorder in adolescence (ASD). Executive, socio-adaptive and behavioral functioning

Resumen Las características de individuos con trastornos del espectro Autista (TEA) persistente (TEA-P) o con TEA remitente (TEA-R) en el tiempo son poco conocidas. Este estudio longitudinal se planteó con tres objetivos: 1) determinar la tasa de persistencia/recuperación en la adolescencia de niños con diagnós tico TEA; 2) comparar el funcionamiento ejecutivo (FE), manifestaciones socio-adaptativas y conductuales de adolescentes TEA-P y TEA-R; y 3) identificar el porcentaje de individuos de los grupos TEA-P y TEA-R con puntuaciones normalizadas en FE y manifestaciones socio-adaptativas y conductuales en la infancia (T1) y en la adolescencia (T2). La muestra en el Tiempo 1 estuvo integrada por 45 niños con TEA (edad 7 a 11 años) de los que 32 mantenían el diagnóstico del trastorno 5 años después. Los padres y profesores cumplimentaron cuestionarios de FE, teoría de la mente (ToM), manifestaciones socio-adaptativas y conductuales en T1 y en T2. El grupo con TEA-P presentó significativamente más problemas y peor evolución en FE, características socio-adaptativas y conductuales que el grupo TEA-R. Los hallazgos destacan la variabilidad de la trayectoria evolutiva del TEA y la necesidad de realizar un seguimiento psicoeducativo y médico frecuente en este trastorno del neurodesarrollo.

Abstract The characteristics of individuals with persis tent ASD (ASD-P) and remittent ASD (ASD-R) are little known. This longitudinal study had threeobjectives1) To determine the persistence and recovery in children with autism spectrum disorder diagnosis in adolescence: 2) To compare executive functioning (EF), socio-adaptive and behavioral manifestations of ASD-P and ASD-R adolescents; and 3) to identify the percentage of normalized individuals in ADS-P and ADS-R groups in EF, socio-adaptive and behavioral manifestation in childhood and adolescence. The sample at T1 was comprised of 45 children with ASD (aged 7-11), maintaining 32 ASD diagnosis five years later. Parents and teachers completed questionnaires on EF, theory of mind, socio-adaptive and behavior difficulties, at both time points. The ASD-P group presented significantly more problems than group ASD-Rand showed worst evolution in EF, socio-adaptive and behavioral domains. Our findings highlight the variability of developmental trajectories of children with ASD.

Quality of life and adherence to dental treatment in adolescents: a longitudinal analytical study

The study aimed to analyze the quality of life, oral health impact on daily activities and its association with adherence to dental treatment, and other factors, among vulnerable adolescents. It is a longitudinal analytical study performed with 15- to 19-year-old adolescents in the city of Piracicaba, São Paulo, from 2014 to 2015. The sample consisted of 476 adolescents referred for the treatment of caries and/or periodontal disease in family health units (initial phase). After 18 months, 325 individuals were assessed to investigate the dental treatment provided (final phase). The response variables considered in the final phase were the Quality of Life (WHOQOL-bref) and the Oral Impacts on Daily Performances (OIDP) questionnaires. The independent variables analyzed were sex, age, treatment adherence, and family cohesion and adaptability. A multiple regression model was used. The data on the physical (p<0.0001), social (p=0.0003), environmental (p<0.0001), and psychological (p<0.0001) domains of the WHOQOL collected in the initial phase had a positive relationship with the same domains assessed in the final phase. The WHOQOL data of the initial phase were associated with the WHOQOL data of the final phase (p=0.0341). The OIDP data of the initial phase were associated with the OIDP data of the final phase (p<0.0001). The OIDP of volunteers who did not adhere to dental treatment showed a higher impact (p=0.0234). The quality of life and impacts on daily performances of adolescents improved between the evaluation periods.

PSS Health: como calcular tamanho de amostra para testes de comparação de médias de dois grupos / PSS Health: how to calculate sample sizes for mean comparison tests between two groups

Dando continuidade à série de artigos que pretendem orientar o usuário na utilização da ferramenta PSS Health para o planejamento de uma pesquisa, esta edição apresenta um passo a passo de como realizar o cálculo e de quais informações são necessárias para comparar médias: de dois grupos dependentes ou independentes, de dois grupos independentes com duas medidas repetidas (deltas), e com duas ou mais medidas repetidas. Todos os exemplos também são ilustrados e disponibilizados em vídeos no canal da Unidade de Bioestatística.

Following the series of articles aiming to guide users in using the PSS Health tool for research planning, this issue presents a step-by-step guide on how to calculate and what information is needed to compare means between 2 dependent or independent groups, 2 independent groups with 2 repeated measures (deltas), and 2 independent groups with 2 or more repeated measures. All examples are accompanied by figures and available in video on the Biostatistics Unit's channel.

Barreiras para participação em programa de reabilitação cardíaca: avaliação antes e durante a pandemia da COVID-19 / Barriers to the participation in a cardiac rehabilitation program: assessment before and during the COVID-19 pandemic

Introdução: O direito à saúde é um dos direitos sociais constitucionalmente garantidos. A realidade brasileira ainda é excludente e também reflete as dificuldades estudadas e superadas por outros países desenvolvidos. No Brasil, menos de 20% dos pacientes que saem de uma internação hospitalar por problemas cardíacos, recebe a indicação para a reabilitação cardíaca. Uma vez inserido em um programa de reabilitação cardíaca (PRC), as maiores barreiras para sua participação estão relacionadas com as comorbidades e/ou estado funcional, necessidades percebidas e acesso. Objetivos: 1) avaliar as barreiras para participação em PRC, na perspectiva de um grupo de participantes, antes da ocorrência da pandemia da COVID-19 (Etapa 1); 2) avaliar as barreiras percebidas pelos participantes para retornarem ao PRC, durante a pandemia da COVID-19 (Etapa 2); 3) comparar as barreiras percebidas nas duas etapas; e 4) avaliar os aspectos físicos e emocionais da qualidade de vida relacionada à saúde (QVRS) dos participantes durante a pandemia da COVID-19. Método: Estudo observacional, analítico e longitudinal realizado em duas etapas com pacientes inseridos em um PCR, fases 2 ou 3, de um hospital universitário do interior paulista. Na primeira etapa, antes da pandemia, 23 participantes responderam presencialmente aos 21 itens da Escala de Barreiras para a Reabilitação Cardíaca (EBRC), usando uma escala ordinal de 1 a 5 (escore total de 21 a 105, com maiores escores indicando maiores barreiras percebidas). Na segunda etapa, realizada por telefone durante o período pandêmico, 18 desses participantes responderam novamente aos itens da EBRC, bem como aos itens dos domínios Aspectos Físicos e Aspectos Emocionais do instrumento Medical Outcomes Study (MOS): 36-Item Short Form Survey (SF-36). Resultados: Na primeira etapa foram entrevistados 23 indivíduos, dos quais três faleceram e dois não apresentaram condições físicas para participarem da segunda entrevista. Concluímos o seguimento de 18 pacientes, sendo a maioria do sexo masculino (66,7%), casada/união estável (60,9%), sem desempenhar atividade ocupacional (91,3%) e residentes da cidade de Ribeirão Preto (52,2%). A média de idade foi de 58,9 (D.P.=12,5) anos, com renda mensal familiar média de R$ 2.072,78 (D.P.=1.397,40) e baixa escolaridade (oito anos de estudo formal, em média). Ao compararmos as barreiras percebidas, antes e durante a pandemia, constatamos a diminuição na percepção dos pacientes sobre as barreiras para a participação em um PRC sendo as diferenças estatisticamente significantes para o escore total da EBRC (p<0,001), para a média total dos itens (p<0,001) e para a maioria dos itens (81%). Durante a pandemia, os participantes avaliaram melhor os aspectos emocionais (M=72,2; D.P.=34,8) do que físicos (M=40,3; D.P.=41,2) da QVRS. Conclusão: No grupo investigado, após a interrupção da participação em um PRC em decorrência da pandemia da COVID-19, os participantes consideraram as barreiras para a adesão ao programa como sendo menores do que aquelas percebidas enquanto estavam inseridos na reabilitação cardíaca. Os resultados encontrados podem ser compreendidos no contexto do isolamento social imposto aos indivíduos com doenças cardíacas e com outras doenças consideradas de risco para o agravamento da condição de saúde diante da contaminação pelo novo coronavírus

Introduction: Health care is one of the social rights constitutionally guaranteed. The Brazilian reality is still exclusionary and also reflects the difficulties studied and overcome by other developed countries. In Brazil, less than 20% of the patients that leave hospitalization due to cardiac problems receive a referral to cardiac rehabilitation. Once inserted in a cardiac rehabilitation program (CRP), the biggest barriers to patients' participation are related to comorbidities and/or functional status, perceived needs and access. Objectives: 1) assess barriers to participation in CRP, from the perspective of a group of participants, before the occurrence of the COVID-19 pandemic (Step 1); 2) assess the barriers perceived by the participants to return to the CRP, during the COVID-19 pandemic (Step 2); 3) compare the perceived barriers in the two phases; e 4) assess the physical and emotional aspects of the participants' health-related quality of life (HRQoL) during the COVID-19 pandemic. Method: Observational, analytical and longitudinal study carried out in two stages with patients enrolled in a CRP, phase 2 or 3, at a university hospital in the countryside of São Paulo. In the first step, before the pandemic, 23 participants responded face-to-face to the 21 items of the Cardiac Rehabilitation Barriers Scale (CRBS), using an ordinal scale from 1 to 5 (total score ranging from 21 to 105, with higher scores indicating greater perceived barriers). In the second step, carried out by telephone during the pandemic period, 18 of those participants responded again to the CRBS items, as well as to the items in the Physical Aspects and Emotional Aspects domains of the Medical Outcomes Study (MOS): 36-Item Short Form Survey (SF -36). Results: In the first step, 23 individuals were interviewed, of which three died and two were not physically able to participate in the second interview. We concluded the follow-up of 18 patients, most of them male (66.7%), married/in a stable relationship (60.9%), with no occupational activity (91.3%) and residents of the city of Ribeirão Preto (52.2%). The mean age was 58.9 (SD=12.5) years, with an average monthly family income of BRL 2,072.78 (SD=1,397.40) and low schooling (eight years of formal schooling, on average). When comparing perceived barriers, before and during the pandemic, we found a decrease in patients' perception of barriers to participation in a CRP, with statistically significant differences for the total CRBS score (p<0.001), for the total average of the items (p<0.001) and for 81% of the items. During the pandemic, participants better rated the emotional (M=72.2; SPD=34.8) than physical (M=40.3; SD=41.2) aspects of HRQoL. Conclusion: In the investigated group, after the interruption of participation in a CRP due to the COVID-19 pandemic, the participants considered the barriers to adherence to the program to be lower than those perceived while they were in cardiac rehabilitation. The results found can be understood in the context of the social isolation imposed on individuals with heart disease and other diseases considered to be at risk for the worsening of their health condition in the face of contamination by the new coronavirus

Longitudinal study on the trajectory and influencing factors of cancer-related fatigue in breast cancer patients during chemotherapy / 中国实用护理杂志

Objective:To investigate the longitudinal trajectory and influencing factors of cancer-related fatigue (CRF) in breast cancer patients during chemotherapy.Methods:From March 2019 to January 2020, breast cancer patients in Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine and Peking Union Medical College Hospital were selected as the research objects to conduct follow-up investigation. The survey tools included general information questionnaire, Cancer-related Fatigue Assessment Scale, International Physical Activity Questionnaire, and the Pittsburgh Sleep Quality Index Scale.Results:A total of 91 patients were included in the study. The incidence of severe CRF at each time point before chemotherapy, 3 weeks after chemotherapy and 6 weeks after chemotherapy were 1.1% (1/91), 8.8% (5/57) and 2.1% (1/48), respectively. The results of the generalized estimation equation showed that the trajectory of the total score CRF firstly increased and then decreased, reaching a peak at 3 weeks after chemotherapy (35.45±13.07), and mild CRF change showed statistical difference ( P<0.05). In addition, BMI and sleep and daytime dysfunction were the influencing factors of the total score of CRF. Disease stage, sleep disturbance and daytime dysfunction were the influencing factors of CRF with different severity. Conclusions:CRF is a prominent problem in breast cancer patients during chemotherapy. Attention should be paid to high-risk individuals with abnormal BMI and daytime function by medical staff.

Longitudinal study on the trajectory and influencing factors of cancer-related fatigue in patients with lung cancer during perioperative period / 中国实用护理杂志

Objective:To explore the changing track of cancer-related fatigue in patients with lung cancer during perioperative period and analyze its influencing factors.Methods:From December 2020 to May 2021, 162 eligible patients with lung cancer were selected in the First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital by convenient sampling method. Mental resilience and social support were investigated before operation (T0);and cancer-related fatigue was investigated before operation (T0),3 days after operation (T1), 1 week after operation (T2), 2 weeks after operation (T3) and 1 month after operation (T4), and Latent Class Growth Model was used to identify the track categories. Logistic regression analysis was used to analyze the influencing factors.Results:Three cancer-related fatigue tracks were fitted in this study, which were no fatigue group (31.7%), increased fatigue group (36.0%) and sustained fatigue group (32.3%). Univariate analysis showed that smoking history ( χ2=14.83, P<0.05), BMI ( χ2=29.67, P<0.05), hemoglobin count ( F=4.57, P<0.05), mental resilience ( F=35.53, P<0.05), social support ( F=47.53, P<0.05) were related to the track category of cancer-related fatigue. Logistic regression analysis showed that smoking history, over weight/obesity, resilience and social support were the predictors of cancer-related fatigue locus ( P<0.05). Conclusions:Perioperative cancer-related fatigue of patients with lung cancer has different change trajectories, patients with higher BMI and lower resilience are more likely to have a tendency of persistent fatigue. Patients with smoking history and lower social support are more likely to have an upward trend of fatigue. For this kind of lung cancer patients, medical staff should take timely and effective intervention measures to improve their cancer-related fatigue.

Longitudinal study of symptoms during chemotherapy in adults with newly diagnosed acute leukemia / 中国实用护理杂志

Objective:To understand the incidence, severity and the change trajectory of symptoms in adult patients with acute leukemia during treatment, so as to provide a reference for clinical medical staff to conduct specific symptom screening and management.Methods:From March 2017 to August 2018, 69 patients who were newly diagnosed with acute leukemia at the Nanfang Hospital of Southern Medical University were conveniently selected. The Memory Symptom Assessment Scale was used to investigate the patients before chemotherapy (T1), after the first chemotherapy (T2), after the second to third chemotherapy (T3) and after the fourth to fifth chemotherapy (T4).Results:The severity score of psychological symptoms in adult patients with acute leukemia at T1, T2, T3, and T4 were 1.00(0.58, 1.42), 1.00(0.83, 1.67), 0.67(0.33, 1.00) and 0.67(0.33, 1.00). The severity score of physical symptoms at T1, T2, T3, and T4 were 0.50(0.21, 0.83), 1.00(0.54, 1.33), 0.75(0.58, 1.17) and 0.92(0.63, 1.08), respectively. The score difference was statistically significant ( H = 28.34, 27.14, both P<0.01) at different time points. The score of physical symptoms reached a peak at T2. In the psychological dimension, the severity and incidence of energy deficiency were higher in T1-T4. Conclusions:Adult acute leukemia patients have different focal symptoms in different treatment stages. Clinical medical staff should provide effective and personalized nursing intervention for patients in different treatment stages.

Effect of frailty on the risk of all-cause mortality —a 12-year follow-up study of community residents aged 45 years and above in Shanghai / 上海预防医学

ObjectiveTo analyze the effect of frailty status on the risk of mortality in a community-based population aged 45 years and above in Shanghai with different characteristics， and to provide further basis for population-based interventions for frailty and prevention of adverse outcomes. MethodsData were derived from baseline data from the Shanghai prospective study on AGEing and adult health （2009-2010） and cohort follow-up of causes of death up to October 30， 2021. Frailty index （FI） scores were constructed from 40 variables. Those with frailty index FI≥0.2 were judged to be in a frail state， and a multifactorial Cox regression model was used to calculate the hazard ratio （HR） to evaluate the effect of frailty status on the risk of death in different age groups by gender. Socioeconomic characteristics （age， residence， marital status， education and family economic level， etc.） and health-related behaviors （smoking， alcohol consumption， fruit and vegetable intake， social participation， etc.） were included as control variables. ResultsThe study included 7 978 subjects， 777 （9.7%） of whom were in a frail state. After （11.3±1.8） years of follow-up， 1 043 （13.1%） individuals were dead， including 214 （27.5%） who were frail. The results of the multifactorial Cox regression analysis showed that the effect of frailty on the risk of death in each subgroup was in descending order of men in the middle-aged group （45‒ years） （HR=2.92， 95%CI： 1.38-6.19）， women in the low-aged elderly group （60‒ years） （HR=1.68， 95% CI： 1.08-2.60）， and women in the old-aged elderly group （≥75 years and older） （HR=1.59， 95%CI： 1.22‒2.06）. ConclusionFrailty is associated with the risk of death， and we should focus on the frailty status of men aged 45~59 years and women aged 60 years and above. Early screening and assessment of frailty status and taking appropriate preventive interventions may reduce the occurrence of adverse outcomes and premature death.

Characteristic of medication compliance behavior in renal transplantation patients / 中南大学学报(医学版)

OBJECTIVES@#After renal transplantation, patients need to take various immunosuppressant, but the drug compliance is poor. The theory of planned behavior suggests that the past medication behavior and subjective norms of individuals are closely related to medication compliance. This study aims to explore the change of medication compliance behavior and its influenting factors for renal transplantation patients at different stages.@*METHODS@#This study was a prospective longitudinal study. The Basel Assessment of Adherence with Immunosuppressive Medication Scale (BAASIS), Medication Belief Scale, Social Support Scale and Quality of Life Scale were used to dynamically follow up renal transplantation patients at pre-operation and 1-month, 6-month, and 12-month after transplantation.@*RESULTS@#A total of 300 patients completed the whole follow-up. The percentage of patients with good medication compliance was 97.60%, 87.30% and 84.30% at 1-month, 6-month and 12-month after transplantation respectively. The life quality of the patients was decreased at 6 months after the operation, and the patients with better self-reported life quality had poor medication compliance. After adjusting for demographic data, the risk of medication incompliance in patients with poor medication compliance before operation was 37.646 times than those with good compliance. Patients who did not use medication reminders had high risk (odds ratio=2.467) of drug non-adherence. The risk of drug non-adherence in patients with more postoperative misgivings was 1.265 times compared with that in patients with less postoperative misgivings.@*CONCLUSIONS@#The medication compliance decreases with the time of transplantation, but the medication compliance of patients with good self-reported life quality is poor. Medication concerns reduce the compliance behavior. Preoperative medication behavior has a significant predictive effect on postoperative behavior. Medication reminder is a protective factor for promoting compliance. Medical staff should pay more attention to preoperative medication belief, behaviors and reminder of using drug so as to provide precise intervention in the renal transplantation patients.

Encuesta sobre el uso de la toma de decisiones compartida en el tratamiento del cáncer de mama de los profesionales involucrados en el manejo del cáncer de mama en Argentina / Survey on the use of shared decision-making in the treatment of breast cancer by professionals involved in the management of breast cancer in Argentina

Introducción: La toma de decisiones compartida (TDC) es un proceso colaborativo que involucra al paciente y al profesional para llegar a una decisión conjunta sobre su atención. Objetivos: Evaluar el conocimiento, la actitud y la aplicación de la TDC entre los profesionales de la salud involucrados en el tratamiento del cáncer de mama (CM). Material y método: Estudio transversal basado en un cuestionario online ad hoc envia- do por varias sociedades profesionales relacionadas con el CM. Este evaluó el grado de conocimiento, actitud, aptitud y uso de la TDC por los profesionales implicados en el manejo del CM. Resultados: La mayoría refirieron conocer los conceptos y los fundamentos sobre la TDC, sin embargo, fueron pocos los profesionales (<30%) que usan la TDC en práctica clínica habitual. Los mastólogos y los profesiona- les que trabajan en Unidades de Mastología refirieron tener mayor conocimiento sobre los fundamentos de la TDC (85.6% vs 76.4%; p < 0.05) y tener más experiencia en su utilización (34.4 vs 24.3; p<0.05). Las principales ventajas destacadas fueron la satisfacción del pacien- te, la mejora en la relación médico-paciente y la reducción del estrés del paciente al ayudarlo a comprender su enfermedad. En cuanto a los obstáculos, destacó la falta de apoyo institucional, la falta de recursos y la falta tiempo en la consulta. Todos los encuestados coin- cidieron que la TDC es una herramienta necesaria para proporcionar una asistencia medica de alta calidad. Conclusiones: Se deben diseñar nuevas políticas para la adecuada formación de los profesionales en la integración de la TDC en la práctica clínica, preparándolos para utilizar la TDC con los recursos y el tiempo adecuados.

Introduction: Shared decision making (SDM) is a collaborative process that involves the patient and the professional to reach a joint decision about care. Objetives: To evaluate the knowledge, attitude and application of SDM among health professionals involved in the treatment of breast cancer (BC). Material and method: Cross-sectional study based on an ad hoc online questionnaire sent by various professional societies to professionals involved in the management of BC. A questionnaire was developed to evaluate the degree of knowledge, attitude, aptitude and use of SDM by the parti- cipating professionals. Results: Most reported knowing the concepts and fundamentals of SDM; however, few professionals (<30%) use SDM in routine clinical prac- tice. Mastologists and professionals who work in Mastology Units reported having greater knowledge about the fundamentals of SDM (85.6% vs 76.4%; p <0.05) and having more experience in its use (34.4 vs 24.3; p <0.05). The main advantages highlighted were patient sa- tisfaction, improved doctor-patient relationship, and reduced patient stress by helping them understand their illness. Regarding the obs- tacles, he highlighted the lack of institutional support, resources and time in the consultation. All respondents agreed that SDM is a neces- sary tool to provide high-quality medical care. Conclusions: New policies should be designed for the adequate training of profes- sionals in integrating SDM in clinical practice, preparing them to use SDM with adequate resources and time.

Associações entre práticas de gestão de pessoas e comportamento de apoio à mudança organizacional: um estudo longitudinal / Associations between people management practices and behavior in support of organizational change: a longitudinal study / Asociaciones entre las prácticas de gestión de personas y el comportamiento de apoyo al cambio organizacional: un estudio longitudinal

Esta pesquisa descreveu as associações entre a percepção das práticas de Gestão de Pessoas, e o comportamento de apoio à mudança dos servidores lotados na Secretaria de Gestão de Pessoas de um órgão público brasileiro. O estudo apresenta o desenho longitudinal, com três ondas de coletas de dados, entre 2016 e 2019 e descreve as alterações estruturais nas Políticas e Práticas de Gestão de Pessoas. Os resultados apontaram que a percepção de Políticas e Práticas de Gestão de Pessoas pode explicar o comportamento de apoio às mudanças em períodos críticos. Esse estudo contribui tanto para a academia quanto para a prática profissional, visto que apresenta as primeiras evidências de resultados de ações feitas pela área de Gestão de Pessoas utilizando critérios alternativos, como aumento de apoio à mudança e o reconhecimento das políticas e práticas implementadas.

This research investigated associations between the perception of people management practices and change-supportive behavior of public servants at the People Management Secretariat of a Brazilian public agency. The study is longitudinal, with three waves of data collection between 2016 and 2019, and describes the structural changes in people management policies and practices. The results showed that the perception of people management policies and practices can explain the behavior that supports change in critical periods. This study contributes both to academia and to practice with the first evidence of the results of actions taken by the people management area using alternative criteria, such as increased support for change and the recognition of implemented policies and practices.

Esta investigación describió las asociaciones entre la percepción de las políticas y prácticas de Gestión de Personas y el comportamiento de apoyo al cambio de los servidores asignados a la Secretaría de Gestión de Personas de un organismo público brasileño. El estudio presenta un diseño longitudinal, con tres oleadas de recolección de datos, entre 2016 y 2019, y describe los cambios estructurales en las Políticas y Prácticas de Gestión de Personas. Los resultados mostraron que la percepción de las Políticas y Prácticas de Gestión de Personas puede explicar el comportamiento de apoyo a los cambios en períodos críticos. Este estudio contribuye tanto a la academia como a la práctica profesional, ya que presenta la primera evidencia de los resultados de las acciones realizadas por el área de Gestión de Personas utilizando criterios alternativos, como un mayor apoyo al cambio y el reconocimiento de las políticas y prácticas implementadas.

Diagnóstico de Fibrilação Atrial na Comunidade Utilizando Eletrocardiograma e Autorrelato: Análise Transversal do ELSA-Brasil / Atrial Fibrillation Diagnosis using ECG Records and Self-Report in the Community: Cross-Sectional Analysis from ELSA-Brasil

Resumo Fundamento: A fibrilação ou flutter atrial (FFA) é a arritmia cardíaca sustentada mais comum. Existem poucos dados sobre a epidemiologia da FFA na América do Sul. Objetivo: O presente estudo procurou descrever a epidemiologia clínica da FFA e o uso de anticoagulantes na avaliação da linha de base do Estudo Longitudinal da Saúde do Adulto (ELSA-Brasil). Métodos: Foram analisados dados de 13.260 participantes do ELSA-Brasil. A FFA foi definida pelo eletrocardiograma ou por autorrelato. Modelos de regressão logística foram construídos para analisar fatores associados à FFA. Este estudo também analisou se idade e sexo estavam associados ao uso de anticoagulantes para evitar acidente vascular cerebral. O nível de significância foi de 5%. Resultados: A idade mediana foi de 51 anos, e 7.213 (54,4%) participantes eram mulheres. A FFA foi detectada em 333 (2,5%) participantes. O aumento da idade (razão de chances [RC]:1,05; intervalo de confiança de 95% [IC95%]: 1,04-1,07), hipertensão (RC:1,44; IC95%:1,14-1,81) coronariopatia (RC: 5,11; IC95%:3,85-6,79), insuficiência cardíaca (RC:7,37; IC95%:5,00-10,87) e febre reumática (RC:3,38; IC95%:2,28-5,02) foram associadas à FFA. Dos 185 participantes com FFA e pontuação no CHA2DS2-VASc≥2, apenas 20 (10,8%) usavam anticoagulantes (50,0% entre aqueles com FFA no eletrocardiograma de linha de base). O uso de anticoagulantes nesse grupo foi associado a maior idade (1,8% vs 17,7% naqueles com idade ≤ 54 e ≥ 65 anos, respectivamente; p=0,013). Observou-se uma tendência ao menor uso de anticoagulantes em mulheres (7,1% vs. 16,4% em mulheres e homens, respectivamente; p=0,055). Conclusões: No recrutamento do ELSA-Brasil, 2,5% dos participantes tinham FFA. O baixo uso de anticoagulantes era comum, o que representa um desafio para os cuidados de saúde nesse cenário.

Abstract Background: Atrial fibrillation or flutter (AFF) is the most common sustained cardiac arrhythmia. Limited data can be found on AFF epidemiology in South America. Objective: The present study sought to describe the clinical epidemiology of AFF and the use of stroke prevention medication in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline assessment. Methods: This study analyzed data from 13,260 ELSA-Brasil participants. AFF was defined according to ECG recording or by self-report. Logistic regression models were built to analyze factors associated with AFF. This study also analyzed if age and sex were associated with anticoagulant use for stroke prevention. Significance level was set at 5%. Results: Median age was 51 years and 7,213 (54.4%) participants were women. AFF was present in 333 (2.5%) participants. Increasing age (odds ratio [OR]:1.05; 95% confidence interval [95%CI]: 1.04-1.07), hypertension (OR:1.44; 95%CI: 1.14-1.81), coronary heart disease (OR: 5.11; 95%CI: 3.85-6.79), heart failure (OR:7.37; 95%CI: 5.00-10.87), and rheumatic fever (OR:3.38; 95%CI: 2.28-5.02) were associated with AFF. From 185 participants with AFF and a CHA2DS2-VASc score ≥2, only 20 (10.8%) used anticoagulants (50.0% among those with AFF in the baseline ECG). Stroke prevention in this group was associated with a higher age (1.8% vs 17.7% in those aged ≤ 54 and ≥ 65 years, respectively; p=0.013). A trend towards a reduced anticoagulant use was observed in women (7.1% vs. 16.4% in women and men, respectively; p=0.055). Conclusions: At the ELSA-Brasil baseline, 2.5% of the participants had AFF. The lack of stroke prevention was common, which is an especially challenging point for healthcare in this setting.